A trait is only as good as the promoter that drives it. The right promoter expresses your gene at the level you need, in the right tissue and under the right condition. The wrong one wastes a valuable gene. Off-the-shelf and viral promoters like CaMV 35S rarely give crops that precision, and reusing the same one across a construct invites homology-dependent silencing.

Building a promoter to specification is hard. The elements that set strength, tissue and condition specificity are difficult to read from sequence, and combining them into one compact, well-behaved promoter is harder still.

Annogen develops that promoter tailored for you. Using SuRE™, we measure large libraries of promoters, enhancers and their variants directly in cells from your crop, then combine and refine the strongest elements into candidates that match your target expression profile, from native, gene-pool-derived designs to fully synthetic ones. Every candidate is validated by measurement, not predicted.

Because we control how a promoter is built, we can design toward your regulatory route as well as your trait. Where you are aiming for the EU’s new-genomic-techniques category 1 (NGT1), for plants that could also have arisen through conventional breeding, we can restrict the design to native, gene-pool sequences and a bounded set of edits, rather than the foreign elements, such as viral promoters, that would place a product in the GMO track.

You bring the crop, the trait and the target gene. We deliver a focused set of bespoke promoter candidates, ready to take into plant testing and yours to own: native, novel and built for the job, rather than adapted from a well-worn part.