Where a transgene integrates into the genome affects how it is expressed: its level, stability and whether it remains active over time. Annogen’s AIM™ platform analyzes the expression characteristics of more than 100,000 integration sites in parallel, generating a comprehensive map of which genomic locations support the expression behavior you need. Studies can be designed to identify novel, patentable loci giving your team a data-driven basis for choosing between targeted integration strategies rather than relying on a handful of historically characterized sites.
Identify loci that support stable, high-level transgene expression in T cells, NK cells or other therapeutic cell types including loci induced upon activation.
Map favorable integration sites in CHO, HEK293 or other producer cell lines to support landing pad strategies and identify loci associated with high, stable titers.
AIM™ studies can be designed to identify novel, patentable integration sites adding IP protection around the genomic context of your expression system.
Let’s start with your biological system.
Share your challenge, question or development goal. We will help you explore how one of our solutions could support the decisions ahead.
