Annogen designs and optimises the gene regulatory elements, mainly promoters, that determine where, when and how strongly your gene of interest is expressed. Our SuRE platform measures the activity of millions of regulatory sequences directly in relevant cells or organisms, so the elements we deliver are validated by experiment rather than predicted. You decide the expression profile you need; we find and build the element that achieves it.

Hundreds of millions in a single experiment. That scale is the point: rather than testing a handful of candidate promoters, we survey the full design space and let the data show which elements perform best for your system.

The standard readout is transcriptional, measured by sequencing expressed barcodes, which lets us quantify very large libraries at once. Where a project needs it, we can discuss protein-level validation as a follow-up step.

We can design inducible systems around several independent triggers, and a TET-operator can be built in where you want it. If you are looking to avoid specific third-party components, that is worth raising early so we design accordingly.

Durability matters, so it is part of how we design rather than an afterthought. Expression stability depends on the element, the integration context and the cell type, and we can build longer-term readouts into a project where it is critical to your application.

Annogen's SuRE platform is species-agnostic. We have worked in human, non-human primate, mouse and various livestock, as well as crops such as corn, soy and tomato.

Both non-exclusive licences to existing elements and exclusive arrangements for bespoke work are possible. Which applies depends on the element and the scope, and we are glad to discuss the options directly.