Functional screening of promoters, enhancers and their variants, measured directly in your crop.
Where gene expression determines therapy safety and efficacy
Turn regulatory DNA into traits
Find the promoters, enhancers and variants that drive precise expression in the right tissue, stage and condition.
You may already know the trait you want to improve, the gene or pathway behind it, and the editing tool to use. The critical uncertainty is which change to make.
Crop traits are set by which genes a plant carries, and by how, where and when those genes are expressed. That control sits in regulatory DNA, which is hard to read from sequence alone. Testing every possible change directly in plants is rarely realistic.
Annogen helps breeders and pre-breeders find and validate regulatory sequences, and the natural variation within them, measured directly in your crop rather than predicted from a model. This shows which changes to make by mutagenesis or gene editing to reach gain-of-function, for example raising expression of a target gene more than tenfold in suitable cases.
The outcome: existing traits improved and new traits unlocked, for commercially relevant crops of the future.
We measure which non-coding variants actually shift expression, so you know which to select from an EMS population or introduce by targeted editing to reach your trait.
Annogen uncovers native regulatory elements for precise gene expression.
Generate bespoke, highly sensitive data sets to train and improve your ML/AI models
Develop crop-specific promoters around the expression needs of your trait.
Generate large-scale plant data to improve regulatory element prediction and design.
De-risk regulatory targets, accelerate trait development.
We don’t settle for good enough. We explore the full design
space to understand what works best, instead of generating quick designs based on limited available data.
Everything we do is grounded in real experimental data. No black boxes, no guesswork. We deliver validated designs rather than predictions to be validated.
We believe biological systems can be understood, designed and controlled. That belief drives how we design, test and optimize our gene expression systems.
Identify the regulatory changes worth validating in plants.
SuRE™ empirically screens promoters, enhancers and their variants at scale in plant-relevant systems, revealing which changes shift expression in the direction your trait requires.
Exhaustive, empirical screening of regulatory sequences in your own crop, giving you validated elements, not predictions. We believe control of gene expression is the foundation of the next generation of crops.
What can we do for you?
