Expression systems built around your therapy

Off-the-shelf promoters

Human genome-based regulatory elements, experimentally validated and ready for evaluation and licensing for your cell or gene therapy program.

What it involves

For programs where speed matters, or where a well-characterized element already fits, a bespoke design may not be needed. Annogen offers a growing portfolio of off-the-shelf promoters for evaluation and licensing. Each has been developed with the SuRE™ platform and validated in relevant cell systems, including in vivo. They are human genome-based, avoiding the viral or synthetic exogenous sequences used by many catalog promoters, which improves expression characteristics and stability and eases regulatory approval.

Available Promoters

Strong housekeeping
Skeletal muscle
Liver
Regulatory T-cell (in development)
Neuro-inflammation inducible
(Pan)Neural
Conventional T-cells
Cardiac
Microglia
T-cell activation inducible
Kidney (in development)

How can you evaluate our promoters?

You can test our promoters before committing to anything. Annogen offers a standard evaluation period of 6 months, during which selected promoters can be provided in a standard backbone or cloned into your vector, either by Annogen or a third party of choice. The licensing option, under predefined terms, remains available until the end of the evaluation period and may be exercised at the evaluator’s sole discretion. In some cases, exclusivity is an option as well

Frequently Asked Questions

We imagine there could be some questions you want to ask us. Discover the most frequently asked questions about this subject right here. 

How do your promoters compare to standard benchmarks (EF1a, CMV, CAG, MND)?
How do you screen for cell-type specificity, not just strong expression?
Can I evaluate an off-the-shelf promoter before licensing it?
Can I evaluate your sequences without sharing my proprietary vector backbone with Annogen?
Do you have a standard evaluation agreement, and how long does the evaluation period run?

Interested?

Let’s start with your goals.

Share your challenges, questions or ambitions. We will help you explore how our off-the-shelf promoters can support the decisions ahead. 

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