Annogen designs and optimises the gene regulatory elements, mainly promoters, that determine where, when and how strongly your gene of interest is expressed. Our SuRE platform measures the activity of millions of regulatory sequences directly in relevant cells or organisms, so the elements we deliver are validated by experiment rather than predicted. You decide the expression profile you need; we find and build the element that achieves it.

It is real, large-scale wet-lab measurement, not prediction. SuRE screens millions of regulatory sequences in living cells and reads out their actual activity, which is why we can show what works rather than estimate it. We increasingly use this data to train models that design new sequences, but the empirical measurement stays at the core.

Hundreds of millions in a single experiment. That scale is the point: rather than testing a handful of candidate promoters, we survey the full design space and let the data show which elements perform best for your system.

The standard readout is transcriptional, measured by sequencing expressed barcodes, which lets us quantify very large libraries at once. Where a project needs it, we can discuss protein-level validation as a follow-up step.

Individual elements are usually around 500 base pairs, which covers most promoters and UTRs. We understand that plant promoters may entail several kilobases. Longer sequences are therefore possible with additional design steps, and the elements in a library do not all need to be the same length.